Much is different.
The prem 7's are late. These are typically squads with mainly senior academy junior main squad players. Last year the only team that didn't do this so much was Sarries, and they won. The year before the exception was Wasps, and they won. I guess availability of suitable players is a factor (injuries etc). That was certainly the case with Wasps two years ago.
It is a test of stamina, and in the final game last year it was plain that Wasps were running on empty, and Sarries were not.
So, a certain number of your squad are going to have had a stamina test (if you get through to the finals) already.
Previous years there was then a rest for these players. Not so this year.
I am not sure how hard Wasps will want to win at the Prem Cup. Dai's #1 focus will be finishing in the top 6 of the GP, plus getting past the first phase of European games. I cannot think he will be much concerned about the Prem Cup. I suspect he will try to bed in some working 'sets' of players to see who gels best with who.
I think it will work out OK.