Lee Blackett has named his side to host London Irish in Gallagher Premiership Round 11 on Sunday.
There are four personnel changes and three positional switches from the team that was named to take on Toulouse, before it was postponed.
Jacob Umaga, Elliott Stooke, Ali Crossdale and Tom Willis all return to the starting team.
Willis is in line to make his 50th Wasps appearance, as he starts at number eight.
The side is captained by Brad Shields, who switches to openside flanker, after he had his ban overturned on appeal. Alfie Barbeary completes the back row at blindside flanker.
Stooke is joined by Vaea Fifita in the second row. Tom West and Biyi Alo start as the props again. They pack down alongside hooker Dan Frost.
Crossdale starts at full-back and is joined in the back three by Francois Hougaard and Luke Mehson.
Umaga starts at fly half, as he hooks up with half-back partner Sam Wolstenholme.
Jimmy Gopperth and Josh Bassett form the centre partnership.
On the bench, prop Rodrigo Martinez is in line to make his Wasps debut. Tom Cruse and Jeffery Toomaga-Allen return from injury to make up the other front row replacements.
Michael Le Bourgeois is in line to make his 50th Premiership appearance from amongst the substitutes. He is joined by Tim Cardall, Thomas Young, Will Porter and Zach Kibirige as the other replacements.
Wasps team to face London Irish at the Coventry Building Society Arena on Boxing Day (kick-off 3:00pm)
Wasps (First-team appearances)
15 Ali Crossdale (7)
14 Francois Hougaard (4)
13 Josh Bassett (159)
12 Jimmy Gopperth (137)
11 Luke Mehson (4)
10 Jacob Umaga (58)
9 Sam Wolstenholme (23)
1 Tom West (58)
2 Dan Frost (6)
3 Biyi Alo (23)
4 Vaea Fifita (
5 Elliott Stooke (9)
6 Alfie Barbeary (17)
7 Brad Shields (62) (c)
8 Tom Willis (49)
Replacements
16 Tom Cruse (103)
17 Rodrigo Martinez (0)
18 Jeffery Toomaga-Allen (54)
19 Tim Cardall (38)
20 Thomas Young (148)
21 Will Porter (37)
22 Michael Le Bourgeois (66)
23 Zach Kibirige (57)
Unavailable (18): Charlie Atkinson, Malakai Fekitoa, James Gaskell, Ben Harris, Robin Hislop, Joe Launchbury, Elliot Millar-Mills, Ryan Mills, Matteo Minozzi, Ben Morris, Paolo Odogwu, Gabriel Oghre, Dan Robson, Will Simonds, Sam Spink, Theo Vukasinovic, Marcus Watson, Jack Willis.