Lee Blackett has named his side to host Saracens at the Coventry Building Society Arena in Gallagher Premiership Round 14 on Sunday.
There are seven personnel changes and three positional switches from the team that took on Munster last Sunday.
Club Captain Joe Launchbury makes his long-awaited return to the starting line-up at lock. He forms the second-row partnership with Elliott Stooke.
Vaea Fifita returns to action, as he plays at blindside flanker for the first time in his Wasps career. Fifita is joined in the back row by Brad Shields, who starts at number eight for the first time this season, and Gabriel Oghre at openside flanker.
In the front row, Biyi Alo is back at tighthead prop, as he joins Tom Cruse and Rodrigo Martinez.
In the backs there is a new midfield pairing, as Jimmy Gopperth is joined by Sam Spink. The duo formed the centre partnership that took to the field in the win over Leicester Tigers earlier this month.
Ali Crossdale misses out with an injury picked up against Munster. That means Marcus Watson switches from the wing to cover full-back, while Paolo Odogwu moves onto the right wing. Josh Bassett completes the back three.
Dan Robson forms the half-back partnership with Charlie Atkinson once more.
On the bench, Malakai Fekitoa makes his long-awaited return from injury. He is joined by Michael van Vuuren, Tom West, Elliot Millar-Mills, James Gaskell, Sam Wolstenholme and Rob Miller as the other replacements.
Wasps team to face Saracens at the Coventry Building Society Arena on Sunday (kick-off 3:00pm)
Wasps (First-team appearances)
15 Marcus Watson (61)
14 Paolo Odogwu (25)
13 Sam Spink (13)
12 Jimmy Gopperth (141)
11 Josh Bassett (164)
10 Charlie Atkinson (21)
9 Dan Robson (143)
1 Rodrigo Martinez (3)
2 Tom Cruse (108)
3 Biyi Alo (27)
4 Joe Launchbury (160) (c)
5 Elliott Stooke (13)
6 Vaea Fifita (10)
7 Gabriel Oghre (55)
8 Brad Shields (67)
Replacements
16 Michael van Vuuren (5)
17 Tom West (61)
18 Elliot Millar-Mills (6)
19 James Gaskell (145)
20 Ben Morris (47)
21 Sam Wolstenholme (27)
22 Malakai Fekitoa (38)
23 Rob Miller (129)
Unavailable (14): Alfie Barbeary, Ali Crossdale, Dan Frost, Ben Harris, Francois Hougaard, Zach Kibirige, Ryan Mills, Matteo Minozzi, Will Porter, Will Simonds, Jacob Umaga, Jack Willis, Tom Willis, Thomas Young.