Head Coach Lee Blackett has named his side to take on Gloucester Rugby in the opening round of the Gallagher Premiership on Sunday 11 September.
New signings, John Ryan and Kiran McDonald will make their first Gallagher Premiership appearance in Black and Gold on Sunday.
Ryan is joined in the front row by Robin Hislop and Tom Cruse.
The side is captained by Joe Launchbury who will be joined in the second row by Kiran McDonald and Tom Willis who topped the leader board last season with most defenders beaten.
Brad Shields will line up alongside Alfie Barbeary to complete the pack in the back-row.
Following an outstanding pre-season performance against both Doncaster Knights & Dragons Matteo Minozzi takes his place at full back.
Josh Mills and Zach Kibirige are on the wings.
Inside them Burger Odendaal and Sam Spink form the centre partnership, while Dan Robson and Charlie Atkinson link up at half-back.
Amongst the replacements, Jack Willis returns from his time in Australia with England Rugby this summer.
Wasps team to face Gloucester Rugby at Kingsholm Stadium on Sunday 11 September, kick off 3pm.
1 Robin Hislop
2 Tom Cruse
3 John Ryan
4 Joe Launchbury (C)
5 Kiran McDonald
6 Tom Willis
7 Brad Shields
8 Alfie Barbeary
9 Dan Robson
10 Charlie Atkinson
11 Josh Bassett
12 Burger Odendaal
13 Sam Spink
14 Zach Kibirige
15 Matteo Minozzi
Replacements
16 Dan Frost
17 Elliot Millar-Mills
18 Biyi Alo
19 Ben Morris
20 Jack Willis
21 Will Porter
22 Ryan Mills
23 Ali Crossdale