If England need to win and score lots of points then EJ needs to pick a team that is best suited to do that. Italy will compete but don't have the fire power to trouble England so he should be able to throw in some inexperienced guys too and see how they perform with established players on the bench. I'd go with:
Malins, May, Slade, Lawrence, Thorley, Umaga, Robson, Obano, Dunn, West, Itoje, Launchbury, Willis, Underwood, Curry. Bench George, Genge/M Vunipola, Sinkler, J Hill/Ewels, Earl, Youngs, Farrell, Watson.
But of course we know he won't!