Lee Blackett has named his side to face Exeter at the Coventry Building Society Arena in Gallagher Premiership Round Five on Saturday.
There are four personnel changes from the victory over Northampton Saints last week.
There is an all-new starting front-row, as Dan Frost makes his first Premiership start at hooker. Tom Cruse misses the game under the HIA protocol. Joining Frost in the front row are Robin ‘Bomber’ Hislop and Jeff Toomaga-Allen.
The only other change sees Michael Le Bourgeois switch to outside centre, with Sam Spink forced out with a hamstring injury. That move sees Jimmy Gopperth come back into the starting side at inside centre, after his impressive kicking display against Saints.
Zach Kibirige starts again on the right wing after scoring against Northampton. Josh Bassett retains his place on the left wing and Marcus Watson is at full back.
In the back-row are captain Brad Shields, Tom Willis and Thomas Young, who was named in the Wales Autumn Nations Cup squad this week.
The second row and half-back partnerships have been unchanged since the beginning of the Premiership season. Elliott Stooke starts alongside fellow recruit Vaea Fifita, while Dan Robson and Jacob Umaga link up for the fourth consecutive week.
On the bench, Patrick Harrison is in line to make his Wasps debut. The Scotland Under 20 hooker is on a short-term loan deal from Edinburgh. Joining him amongst the replacements is Francois Hougaard, who is also in line to make his Wasps debut, having been a late withdrawal last week.
Wasps team to face Exeter at Coventry Building Society Arena on Saturday (kick-off 3:00pm)
Wasps (First-team appearances)
15 Marcus Watson (55)
14 Zach Kibirige (50)
13 Michael Le Bourgeois (61)
12 Jimmy Gopperth (131)
11 Josh Bassett (153)
10 Jacob Umaga (53)
9 Dan Robson (140)
1 Robin Hislop (3)
2 Dan Frost (2)
3 Jeff Toomaga-Allen (48)
4 Vaea Fifita (3)
5 Elliott Stooke (3)
6 Brad Shields (56) (c)
7 Thomas Young (141)
8 Tom Willis (44)
Replacements
16 Patrick Harrison (0)
17 Ben Harris (82)
18 Pieter Scholtz (1)
19 Tim Cardall (31)
20 Nizaam Carr (57)
21 Francois Hougaard (0)
22 Will Simonds (4)
23 Ali Crossdale (3)
Unavailable: Charlie Atkinson, Alfie Barbeary, Malakai Fekitoa, James Gaskell, Joe Launchbury, Rob Miller, Ryan Mills, Paolo Odogwu, Gabriel Oghre, Sam Spink, Theo Vukasinovic, Jack Willis.