Lee Blackett has named his side to face Saracens at StoneX Stadium in Gallagher Premiership Round Six on Sunday.
There are 12 personnel changes from the physical encounter with Exeter last week.
Short-term signings Sebastian de Chaves and Alex McHenry will make their Wasps debuts.
McHenry is joined in the centres by Will Simonds, who makes his first Premiership start at 12.
Francois Hougaard also makes his first start for Wasps. His half-back partner is Jimmy Gopperth who captains the team at fly-half.
There is an all-new starting front-row, Tom West and Tom Cruse return to the side after injuries. Joining them in the front row is Pieter Scholtz.
Nizaam Carr starts his first game since returning to the Club. The number eight has Ben Morris and Thomas Young, who keeps his place at seven, in the back-row alongside him.
In the back three Ali Crossdale starts at full back against his old side. Matteo Minozzi makes his first appearance of the season on the left wing, while Zach Kibirige keeps his place on the right wing.
Debutant de Chaves is joined in the second row by Tim Cardall.
On the bench, Will Holling is in line to make his Wasps debut. The 24-year-old hooker has joined the Club on a short-term loan deal from Doncaster Knights. Joining him amongst the replacements are Elliot Millar-Mills, Tommy Mathews and Luke Mehson, who are also in line to make their Wasps debuts.
Wasps team to face Saracens at StoneX Stadium on Sunday (kick-off 3:00pm)
Wasps (First-team appearances)
15 Ali Crossdale (4)
14 Zach Kibirige (51)
13 Alex McHenry (0)
12 Will Simonds (5)
11 Matteo Minozzi (31)
10 Jimmy Gopperth (132) (c)
9 Francois Hougaard (1)
1 Tom West (55)
2 Tom Cruse (102)
3 Pieter Scholtz (2)
4 Sebastian de Chaves (0)
5 Tim Cardall (32)
6 Ben Morris (45)
7 Thomas Young (142)
8 Nizaam Carr (58)
Replacements
16 Will Holling (0)
17 Robin Hislop (4)
18 Elliot Millar-Mills (0)
19 Elliott Stooke (4)
20 Kieran Curran (1)
21 Will Porter (32)
22 Tommy Mathews (0)
23 Luke Mehson (0)
Unavailable: Charlie Atkinson, Alfie Barbeary, Malakai Fekitoa, Dan Frost, James Gaskell, Ben Harris, Joe Launchbury, Michael Le Bourgeois, Rob Miller, Ryan Mills, Paolo Odogwu, Gabriel Oghre, Dan Robson, Sam Spink, Theo Vukasinovic, Jack Willis.